MAY 2020 – In an independent, ethics-approved, double blind, randomized, placebo controlled clinical trial conducted by Gupte PA et al, Longvida Optimized Curcumin® was evaluated for safety and efficacy against ibuprofen (males and females aged 40-65 yrs).1 The study, published in the Journal of Inflammation Research, found Longvida®, at a daily dose of 800mg, was safe and effective when administered for 90 days.1 Forty-two subjects (n=25 ibuprofen, n=17 Longvida), exhibited significant improvements in VAS and WOMAC scores compared to baseline.1 Findings concluded Solid Lipid Curcumin Particle™ (SLCP™ ) Longvida® was not only safe and effective, but also found Longvida to provide “faster acting pain relief” compared to ibuprofen in the first 30 days.1 Additionally, no significant changes in blood or urine parameters were reported, nor were any serious adverse side effects reported during the study period, further confirming the safety of Longvida Optimized Curcumin®.1
“The promising results from this study further confirm the safety and efficacy of Longvida,” said Leisha Jenkins, Marketing Associate for Verdure Sciences. “Not only is it exciting to see the results from this study, but further establishes Longvida’s capabilities for tangible health benefits for a variety of applications.” Jenkins continued.
More recently, news surrounding nonsteroidal anti-inflammatory drugs, or NSAIDs, has circulated, inciting increased interest in plant-based alternatives. NSAIDs are commonly known to block or impair the initial stage of healing by severely blunting inflammation.2 Conversely, Longvida® supplementation, as examined by the researchers in this study, significantly decreased VAS and WOMAC scores when compared to baseline from day 45 onwards, an effect that was comparable to a low dose of ibuprofen (NSAID).1 Longvida did not produce statistically significant changes in any of the inflammatory markers (i.e. PGE2, TNF α, IL6, IL1β and LTB4), which supports findings from previous studies showing that Longvida does not completely block the inflammatory response, rather mediates a healthy inflammatory response, indicating efficacy in subjective pain scores.1Thus, a low dose of Longvida® modulates the inflammation produced by a stressor due to its immunomodulatory effects and promotes a healthy, balanced inflammatory response.1
The key to the success of Longvida lies within the patented and proprietary Solid Lipid Curcumin Particle Technology, or SLCP™. Developed by University neuroscientists as an absorption promoting technology, SLCP allows the uptake of free curcumin into the bloodstream and target tissues. “As we approach nearly 15 years of commercial availability, we are excited to further delve into the seemingly limitless frontier of tangible health applications and expanding pedigree of science in support of our Optimized Curcumin®,” explained Jenkins. She continued, “With category concerns surrounding adulteration on the rise, it is equally imperative to support an efficacious offering with safety and traceability efforts. This publication not only expands upon the impressive portfolio of supportive efficacy research, but also further substantiates the safety of this long-standing branded ingredient. The mounting research and support for Longvida Optimized Curcumin® truly sets the standard for high-caliber ingredient offerings.” †
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
1 - Gupte PA et al. J Inflamm Res. 2019. 12: 145-152. doi: 10.2147/JIR.S205390
2 - Cleveland Clinic. 2020. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Retrieved May 2020 fromhttps://my.clevelandclinic.org/health/drugs/11086-non-steroidal-anti-inflammatory-medicines-nsaids
About Verdure Sciences®:Verdure Sciences manages ingredient innovation throughout the integration of supply network, production, and research platforms. With an expanding pipeline of proprietary, standardized botanical ingredients supported by pharmacokinetic, pharmacodynamic, and clinical research profiles, we work toward our unified vision to offer safe, effective ingredient solutions. Verdure Sciences® is a registered trademark of Verdure Sciences®, Inc.
About Longvida®:Longvida Optimized Curcumin® is a breakthrough formula of the natural antioxidant curcumin, from the turmeric root, optimized to deliver free curcumin. It was designed by university neuroscientists using a patented Solid Lipid Curcumin Particle (SLCP™) Technology that promotes the uptake of free curcumin to the blood and target tissues. Exclusively licensed to Verdure Sciences, Longvida® is able to bypass initial hydrolysis and deliver bioefficacious levels of unglucuronidated (free) curcumin to the brain and target tissues. Longvida® has been extensively studied by independent researchers globally and offers efficacious amounts of free curcumin at easily managed daily doses.
For a list of current Longvida references, please visit: marketing.vs-corp.com/longvida-science