JULY 2019 – Four years ago, researchers at Swinburne University conducted a study investigating the effects of Longvida® curcumin on cognition and mood in a healthy older population (aged 60-80).1 After 4 weeks of administration, they found that daily Longvida® (400 mg) supplementation led to significant improvements in cognitive function, including in measures for memory, attention, fatigue, stress, and mood when compared to placebo. This groundbreaking clinical trial won Research of the Year with NutraIngredients in the year following its publication.
The promising results of this award-winning trial prompted researchers to conduct a follow-up study aimed at determining whether similar effects were evident following 12 weeks of taking Longvida. We are excited to share that the much-awaited results are in; according to Scholey et al., this follow-up study “confirm[s] that Longvida® improves aspects of mood and working memory in a healthy older cohort.”2
The follow-up study was a double-blind, placebo-controlled, parallel-groups trial with eighty participants aged 50-80. The test subjects were randomized to receive 400 mg/day of Longvida® or a matching placebo. After a baseline assessment, results were measured at 4 and 12 weeks. Cognitive performance, measures of mood, cardiovascular function, and various other blood biomarkers were assessed. Longvida® was well-tolerated with no severe adverse effects.
Compared with placebo, the Longvida® group demonstrated a number of improvements. These included mood effects such as decreased tension, anger, confusion, and total mood disturbance at 4 weeks, lower fatigue scores at both 4 and 12 weeks. Working memory performance was also improved. The study leader Professor Andrew Scholey said “We should exercise some caution as the study hasn’t yet undergone full peer review (although the conference abstracts were peer reviewed). Nevertheless the results of our second trial broadly support and extend the effects of the first study. We are currently further examining the effects of Longvida® on hippocampal functioning.”
Scholey et al. also concluded that Longvida® may hold promise for “alleviating cognitive decline in some populations.”2 This study provides additional support for Longvida’s efficacy to promote healthy aging, and the full publication is eagerly anticipated sometime this year. Kristen Marshall, Marketing Coordinator – Verdure Sciences, said, “We are so excited to see additional support of Longvida’s efficacious capabilities to promote cognitive health and overall well-being. It is very impressive to see a second clinical trial by an astounding group of researchers conclusively support Longvida’s impact on cognitive biomarkers and influence on health.” †
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
About Verdure Sciences®: Verdure Sciences manages ingredient innovation throughout the integration of supply network, production, and research platforms. With an expanding pipeline of proprietary, standardized botanical ingredients supported by pharmacokinetic, pharmacodynamic, and clinical research profiles, we work toward our unified vision to offer safe, effective ingredient solutions. Verdure Sciences® is a registered trademark of Verdure Sciences®, Inc.
About Longvida®: Longvida® Optimized Curcumin is a breakthrough formula of the natural antioxidant curcumin, from the turmeric root, optimized to deliver free curcumin. It was designed by university neuroscientists using a patented Solid Lipid Curcumin Particle (SLCP™) formulation that promotes the uptake of free curcumin to the blood and target tissues. Exclusively licensed to Verdure Sciences, Longvida® is able to bypass initial hydrolysis and deliver bioefficacious levels of unglucuronidated (free) curcumin to the brain and target tissues. Longvida® has been extensively studied by independent researchers globally and offers efficacious amounts of free curcumin at easily managed daily doses.
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- Cox KH et al. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. Centre for Human Psychopharmacology, Swinburne University. J Psychopharmacol. May 2015. (Vol 29) No 5: 642-651. DOI: 10.1177/0269881114552744
- Andrew Scholey, Katherine Cox, Andrew Pipingas, David White, A Highly Bioavailable Curcumin Extract Improves Neurocognitive Function and Mood in Healthy Older People: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial (OR32-05-19), Current Developments in Nutrition, Volume 3, Issue Supplement_1, June 2019, nzz052.OR32–05–19, https://doi.org/10.1093/cdn/nzz052.OR32-05-19